A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 15-22.
Biomedical Sciences
Sex-Specific Association Between Perivascular Inflammation and Plaque Vulnerability. Kinoshita, Daisuke, Keishi Suzuki, Haruhito Yuki, Takayuki Niida, Daichi Fujimoto, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Maros Ferencik, Tsunekazu Kakuta, and Ik-Kyung Jang. Circulation. Cardiovascular Imaging 17 (2): e016178.
Association of Cardiometabolic and Vascular Atherosclerosis Phenotypes on Non-Contrast Chest CT With Incident Heart Failure in Patients With Severe Hypercholesterolemia. Piña, Pamela, Daniel Lorenzatti, Francesco Castagna, Jeremy Miles, Toshiki Kuno, Andrea Scotti, Javier Arce, Ari Feinberg, Dou Huang, Jake Gilman, Ephraim Leiderman, Jonathan Daich, Paul Ippolito, Carlos A. Gongora, Aldo L. Schenone, Lili Zhang, Carlos J. Rodriguez, Michael J. Blaha, Damini Dey, Daniel S. Berman, Salim S. Virani, Jeffrey M. Levsky, Mario J. Garcia, and Leandro Slipczuk. Journal of Clinical Lipidology, February, S1933-2874(24)00020-5.
Wiring the Brain for Wellness: Sensory Integration in Feeding and Thermogenesis: A Report on Research Supported by Pathway to Stop Diabetes. Riera, Céline E. Diabetes 73 (3): 338–47.
Cardiology
S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. Barbier-Torres, Lucía, Jyoti Chhimwal, So Yeon Kim, Komal Ramani, Aaron Robinson, Heping Yang, Jenny Van Eyk, Suthat Liangpunsakul, Ekihiro Seki, José M. Mato, and Shelly C. Lu. International Journal of Biological Sciences 20 (4): 1218–37.
Machine Learning and Bias in Medical Imaging: Opportunities and Challenges. Vrudhula, Amey, Alan C. Kwan, David Ouyang, and Susan Cheng. Circulation. Cardiovascular Imaging 17 (2): e015495.
Reply to the Editor -- Postural Orthostatic Tachycardia Syndrome After COVID-19 Vaccination. Teodorescu, Debbie Lin, and Peng-Sheng Chen. Heart Rhythm, February, S1547-5271(24)00136-X.
Injury Minimization After Myocardial Infarction: Focus on Extracellular Vesicles. Barile, Lucio, and Eduardo Marbán. European Heart Journal, February, ehae089.
Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease. Mesquita, Thassio, Yen-Nien Lin, Shuang Chen, Youngho Lee, Rodrigo Miguel-Dos-Santos, Asli E. Atici, Michael C. Fishbein, Magali Noval Rivas, Moshe Arditi, and Eugenio Cingolani. Arteriosclerosis, Thrombosis, and Vascular Biology, February.
Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality. Ji, Hongwei, Martha Gulati, Tzu Yu Huang, Alan C. Kwan, David Ouyang, Joseph E. Ebinger, Kaitlin Casaletto, Kerrie L. Moreau, Hicham Skali, and Susan Cheng. Journal of the American College of Cardiology 83 (8): 783–93.
Imaging
Meta-Analysis of Normal Reference Values for Right and Left Ventricular Quantification by Cardiovascular Magnetic Resonance. Zhan, Yang, Matthias G. Friedrich, Nandini Dendukuri, Yang Lu, Michael Chetrit, Ian Schiller, Lawrence Joseph, Jaime L. Shaw, Michael L. Chuang, Johannes H. Riffel, Warren J. Manning, and Jonathan Afilalo. Circulation. Cardiovascular Imaging 17 (2): e016090.
10-Year Experience of Utilizing a Stress-First SPECT Myocardial Perfusion Imaging. Han, Donghee, Mark C. Hyun, Robert J. H. Miller, Heidi Gransar, Piotr J. Slomka, Damini Dey, Sean W. Hayes, John D. Friedman, Louise E. J. Thomson, Daniel S. Berman, and Alan Rozanski. International Journal of Cardiology, February, 131863.
Medicine
Pan-Cancer Analysis of RNA 5-Methylcytosine Reader (ALYREF). Ye, Xing, Zhouting Tuo, Kai Chen, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Akira Miyamoto, Koo Han Yoo, Chi Zhang, Wuran Wei, Dengxiong Li, and Dechao Feng. Oncology Research 32 (3): 503–15.
Cancer-Related Cells and Oncosomes in the Liquid Biopsy of Pancreatic Cancer Patients Undergoing Surgery. Shishido, Stephanie N., Emmeline Lin, Nicholas Nissen, George Courcoubetis, Divya Suresh, Jeremy Mason, Arsen Osipov, Andrew E. Hendifar, Michael Lewis, Srinivas Gaddam, Stephen Pandol, Peter Kuhn, and Simon K. Lo. NPJ Precision Oncology 8 (1): 36.
Lipid Droplets in the Endothelium: The Missing Link Between Metabolic Syndrome and Cardiovascular Disease? Jaffe, Iris Z., and S. Ananth Karumanchi. The Journal of Clinical Investigation 134 (4): e176347.
Pumping Iron Burns Fat in Lung Injury. Zuttion, Marilia Sanches Santos Rizzo, and Peter Chen. American Journal of Respiratory Cell and Molecular Biology, February.
What Is the Effect of Preoperative Depression on Outcomes After Minimally Invasive Surgery for Adult Spinal Deformity? A Prospective Cohort Analysis. Agarwal, Nitin, Vijay Letchuman, Raj Swaroop Lavadi, Vivian P. Le, Alexander A. Aabedi, Saman Shabani, Andrew K. Chan, Paul Park, Juan S. Uribe, Jay D. Turner, Robert K. Eastlack, Richard G. Fessler, Kai-Ming Fu, Michael Y. Wang, Adam S. Kanter, David O. Okonkwo, Pierce D. Nunley, Neel Anand, Gregory M. Mundis, Peter G. Passias, Shay Bess, Christopher I. Shaffrey, Dean Chou, and Praveen V. Mummaneni. Journal of Neurosurgery. Spine, February, 1–9.
Epigenomic Analyses Identify FOXM1 as a Key Regulator of Anti-Tumor Immune Response in Esophageal Adenocarcinoma. Ziman, Benjamin, Qian Yang, Yueyuan Zheng, Megha Sheth, Chehyun Nam, Hua Zhao, Le Zhang, Boyan Hu, Neil A. Bhowmick, Uttam K. Sinha, and De-Chen Lin. Cell Death & Disease 15 (2): 152.
Upper Limit of Normal ALT Levels in Health and Metabolic Diseases: Pooled Analysis of 423,355 Individuals With Bootstrap Modelling. Tan, Eunice X., Daniel Q. Huang, Natasha Tang Sook Yee, Zi Hui Wan, Sanjna N. Nerurkar, Justin Chua Ying Kai, Kang Shiong Goh, Cheng Han Ng, Mark Muthiah, Yu Zhou, Amanda Woodward, Michael H. Le, Yee Hui Yeo, Scott Barnett, Ramsey Cheung, and Mindie H. Nguyen. Alimentary Pharmacology & Therapeutics, February.
Automated Vessel Specific Coronary Artery Calcification Quantification With Deep Learning in a Large Multi-Center Registry. Williams, Michelle C., Aakash D. Shanbhag, Jianhang Zhou, Anna M. Michalowska, Mark Lemley, Robert Jh Miller, Aditya Killekar, Parker Waechter, Heidi Gransar, Serge D. Van Kriekinge, Valerie Builoff, Attila Feher, Edward J. Miller, Timothy Bateman, Damini Dey, Daniel Berman, and Piotr J. Slomka. European Heart Journal. Cardiovascular Imaging, February, jeae045.
Burning Mouth in Oncology Care: A Systematic Review. Normando, Ana Gabriela Costa, Alan Roger Santos-Silva, and Joel B. Epstein. Supportive Care in Cancer, 32 (3): 170.
Precision Medicine in Rheumatology: The Promise of Ultrasound-Guided Synovial Biopsy, Barriers to Its Implementation in the United States, and Proposed Solutions. Horowitz, Diane Lewis, Arthur M. Mandelin, Darren Tabechian, and Ami Ben-Artzi. Current Rheumatology Reports, February.
Differences in Health Care Transition Knowledge, Attitudes, and Behaviors Among Graduate Medical Trainees From Pediatrics- and Adult-Focused Programs: Results From a Cross-Sectional Survey. Patel, Jay, Allison Liu, Jesse Huang, Jessica I. Gold, Nabil Abou Baker, and Rita Rossi Foulkes. Journal of General Internal Medicine, February.
The Therapeutic Potential of Immunoengineering for Systemic Autoimmunity. McBride, David A., Ryan M. Jones, Nunzio Bottini, and Nisarg J. Shah. Nature Reviews. Rheumatology, February.
Operationalizing Multidisciplinary Liver Tumor Boards for Hepatocellular Carcinoma. Ho, Chanda, Marwan Ghabril, Alexander Kuo, Marina Serper, Elliot B. Tapper, and Sumeet K. Asrani. Liver Transplantation, February.
Starting the Journey: Understanding the Roles of Complement Proteins in Liver Diseases Through Mendelian Randomization. Rezaee-Zavareh, Mohammad Saeid, Naomy Kim, and Ju Dong Yang. Clinical and Molecular Hepatology, February.
Assessment of IgM DSAs in Transplant Recipients: Relationship to De Novo IgG DSAs and Risk for Antibody Rejection. Zhang, Xiaohai, and Stanley C. Jordan. Transplantation Direct 10 (3): e1583.
Neurosurgery
Multimodal Single-Neuron, Intracranial EEG, and fMRI Brain Responses During Movie Watching in Human Patients. Keles, Umit, Julien Dubois, Kevin J. M. Le, J. Michael Tyszka, David A. Kahn, Chrystal M. Reed, Jeffrey M. Chung, Adam N. Mamelak, Ralph Adolphs, and Ueli Rutishauser. Scientific Data 11 (1): 214.
Unilateral Internuclear Ophthalmoplegia and Upbeat Nystagmus Due to a Rapidly Enlarging Cavernous Malformation and Associated Developmental Venous Anomaly. Chen, Amalie, Carson Quinn, Michael J. Alexander, Joseph F. Rizzo, and Marcelo Matiello. Journal of Neuro-Ophthalmology, February.
Between a Rock and a Hard Place: The Role of DA Induced Tumor Fibrosis in Prolactinoma Management. Mamelak, Adam N. The Journal of Clinical Endocrinology and Metabolism, February, dgae090.
Response to Letter to the Editor From Salle et Al.: ‘A Prospective Multi-Center Observational Study of Surgical Versus Non-Surgical Management for Pituitary Apoplexy.’ Mamelak, Adam N. The Journal of Clinical Endocrinology and Metabolism, February, dgae091.
Use of the pRESET LITE Thrombectomy Device in Combined Approach for Medium Vessel Occlusions: A Multicenter Evaluation. Wang, Maud, Hans Henkes, Sherief Ghozy, James E. Siegler, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Jeremy J. Heit, Ahmad Sweid, Kareem El Naamani, M.A.D.-M.T. Consortium, et al. Neuroradiology, February.
OBGYN
Cytochrome P450 Inhibitor/Inducer Treatment Patterns Among Patients in the United States With Advanced Ovarian Cancer Who Were Prescribed or Were Eligible for Poly (Adenosine Diphosphate [ADP]-Ribose) Polymerase Inhibitors in the First-Line Maintenance Setting. Rimel, Bobbie J., Dana M. Chase, Jessica Perhanidis, Armen A. Ghazarian, Ella Xiaoyan Du, Travis Wang, Jinlin Song, Amanda K. Golembesky, Jean A. Hurteau, Linda Kalilani, Ritu Salani, and Bradley J. Monk. Gynecologic Oncology Reports 51 (February): 101332.
Characteristics Associated With Blood Transfusion Among Women Undergoing Laparoscopic Myomectomy: A NSQIP Study. Hamilton, Kacey M., Connie Liao, Gabriel Levin, Moshe Barnajian, Yosef Nasseri, Catherine Bresee, Mireille D. Truong, Kelly N. Wright, Matthew T. Siedhoff, and Raanan Meyer. American Journal of Obstetrics and Gynecology, February, S0002-9378(24)00081-4.
A Cross-Sectional Assessment of YouTube as a Source of Information on Diet and Supplements for Polycystic Ovary Syndrome. Sweterlitsch, Katherine M., Katherine L. VanHise, Ndeye Konate, Bryn E. Willson, Margareta D. Pisarska, Erica T. Wang, and Jessica L. Chan. Fertility and Sterility, February, S0015-0282(24)00110-9.
Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology. Suzuki, Ken, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kim M. Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Giorgio E. M. Melloni, Stavroula Kanoni, Nigel W. Rayner, Ozvan Bocher, Eleftheria Zeggini, et al. Nature, February.
Fallopian Tube Single Cell Analysis Reveals Myeloid Cell Alterations in High-Grade Serous Ovarian Cancer. Brand, Joshua, Marcela Haro, Xianzhi Lin, B. J. Rimel, Stephanie M. McGregor, Kate Lawrenson, and Huy Q. Dinh. iScience 27 (3): 108990.
Orthopaedics
Psoriasis Is a Risk Factor for Surgical Site Infection After Primary TKA. Durst, Caleb, Lily Rajaee, Kenny Chang, Anderson Lee, and Sean Rajaee. Clinical Orthopaedics and Related Research, February.
Letter to the Editor Regarding ‘3D Printed Pedicle Screw Guides Reduce the Rate of Intraoperative Screw Revision in Adolescent Idiopathic Scoliosis Surgery’ by Jeong et Al. Nilssen, Paal K., David L. Skaggs, and Kenneth D. Illingworth. The Spine Journal, 24 (3): 560.
Pathology and Laboratory Medicine
Protocol to Create a Murine Subcutaneous Air Pouch for the Study of Monosodium Urate Crystal-Induced Gout. Devi, Savita, Christian Stehlik, and Andrea Dorfleutner. STAR Protocols 5 (1): 102888.
INHBA(+) Cancer-Associated Fibroblasts Generate an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. Hu, Ye, Maria Sol Recouvreux, Marcela Haro, Enes Taylan, Barbie Taylor-Harding, Ann E. Walts, Beth Y. Karlan, and Sandra Orsulic. NPJ Precision Oncology 8 (1): 35.
Pediatrics
Don’t Anchor on Me! Tantoco, Ann-Marie, Ajay Bhasin, Maria Santos, Art Kastl, and Adam Bracken. Journal of Hospital Medicine, February.
28 NICUs Participating in a Quality Improvement Collaborative Targeting Early-Onset Sepsis Antibiotic Use. Payton, Kurlen S. E., Mihoko V. Bennett, Joseph Schulman, William E. Benitz, Lisa Stellwagen, Gary L. Darmstadt, Jenny Quinn, Alexandria I. Kristensen-Cabrera, Courtney C. Breault, Michael Bolaris, Linda Lefrak, Jeff Merrill, and Paul J. Sharek. Journal of Perinatology, February.
Surgery
The First Generation of Asian American Pediatric Surgical Trainees in North America. Gow, Kenneth W., XiaoYue Han, Eugene S. Kim, Meera Kotagal, Grace Mak, and Sanjay Krishnaswami. The Journal of Surgical Research 296 (February): 636–42.
The Promise of Complement Therapeutics in Solid Organ Transplantation. Steggerda, Justin A., and Peter S. Heeger. Transplantation, February.
Urinary Tract Infections in Pediatric Orthopedic Surgical Patients: A Single Institution National Surgical Quality Improvement Program Study. Brar, Ravinder K., Lucas Weiser, Hillary L. Copp, and Kristin S. Livingston. Journal of Pediatric Orthopedics. Part B, February.
Absence of CD80 Reduces HSV-1 Replication in the Eye and Delays Reactivation but Not Latency Levels. Jaggi, Ujjaldeep, Harry H. Matundan, Jay J. Oh, and Homayon Ghiasi. Journal of Virology, February, e0201023.
ASO Author Reflections: Considerations in the Debate on Sentinel Node Biopsy in Older Patients With ER+/Her2- Breast Cancer. Chung, Alice. Annals of Surgical Oncology, February.
Development of the 12-Item Facial Complaints Evaluation Scale (FaCES-12). Higgins, Thomas S., Travis A. Shutt, Jonathan Y. Ting, Elisa A. Illing, Dennis M. Tang, Nikitha Kosaraju, Kevin Potts, Liz Cash, David Liu, Kathleen A. Sheeley, and Arthur W. Wu. The Annals of Otology, Rhinology, and Laryngology, February, 34894241233034.
