A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 8-15.
Biomedical Sciences
CT Attenuation of Periaortic Adipose Tissue in Abdominal Aortic Aneurysms. Debono, Samuel, Evangelos Tzolos, Maaz B. J. Syed, Jennifer Nash, Alexander J. Fletcher, Marc R. Dweck, David E. Newby, Damini Dey, Rachael O. Forsythe, and Michelle C. Williams. Radiology. Cardiothoracic Imaging 6 (1): e230250.
Pancreatic ? Cell Function versus Insulin Resistance: Application of the Hyperbolic Law of Glucose Tolerance. Bergman, Richard N. The Journal of Clinical Investigation 134 (3): e176738.
Stromal-Derived MAOB Promotes Prostate Cancer Growth and Progression. Pu, Tianjie, Jing Wang, Jing Wei, Alan Zeng, Jinglong Zhang, Jingrui Chen, Lijuan Yin, Jingjing Li, Tzu-Ping Lin, Jonathan Melamed, Eva Corey, Allen C. Gao, and Boyang Jason Wu. Science Advances 10 (6): eadi4935.
(Pro)Renin Receptor Signaling in Hypothalamic Tyrosine Hydroxylase Neurons Is Required for Obesity-Associated Glucose Metabolic Impairment. Pan, Shiyue, Lucas A C Souza, Caleb J. Worker, Miriam E. Reyes Mendez, Ariana Julia B. Gayban, Silvana G. Cooper, Alfredo Sanchez Solano, Richard N. Bergman, Darko Stefanovski, Gregory J. Morton, Michael W. Schwartz, and Yumei Feng Earley. JCI Insight, February, e174294.
Cardiac Surgery
Mitral Valve Surgery after Failed Transcatheter Edge-to-Edge Repair: Operative Techniques and Institutional Experience. Malas, Jad, Rishab Humar, Qiudong Chen, Achille Peiris, Dominick Megna, Michael E. Bowdish, Joanna Chikwe, Alfredo Trento, and Dominic Emerson. JTCVS Techniques 23 (February): 47–48.
Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction. Doiron, Jake E., Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, and David J. Lefer. Journal of the American Heart Association, February, e032646.
Cardiology
Pulmonary Primary Oxysterol and Bile Acid Synthesis as a Predictor of Outcomes in Pulmonary Arterial Hypertension. Alotaibi, Mona, Lloyd D. Harvey, William C. Nichols, Michael W. Pauciulo, Anna Hemnes, Tao Long, Jeramie D. Watrous, Arjana Begzati, Jaakko Tuomilehto, Aki S. Havulinna, Teemu J. Niiranen, Pekka Jousilahti, Veikko Salomaa, Thomas Bertero, Nick H. Kim, Ankit A. Desai, Atul Malhotra, Jason X.-J. Yuan, Susan Cheng, Stephen Y. Chan, and Mohit Jain. bioRxiv: The Preprint Server for Biology, January,01.20.576474.
Effects of Pericardiocentesis on Renal Function and Cardiac Hemodynamics. Shmueli, Hezzy, Maulin Shah, Yatindra Patel, Long-Co Nguyen, Hannah Hardy, Florian Rader, and Robert J. Siegel. Echocardiography (Mount Kisco, N.Y.) 41 (2): e15764.
Recommended and Observed Statin Use Among US Adults With and Without Cancer. Kobo, Ofer, Erin D. Michos, Ariel Roguin, Rodrigo Bagur, Martha Gulati, and Mamas A. Mamas. European Journal of Preventive Cardiology, February, zwae057.
Management of Infectious Disease Syndromes in Thoracic Organ Transplants and Mechanical Circulatory Device Recipients: A Delphi Panel. Luong, Me-Linh, Yoshiko Nakamachi, Fernanda P. Silveira, Catherine O. Morrissey, Lara Danziger-Isakov, Erik A. M. Verschuuren, Cameron R. Wolfe, Denis Hadjiliadis, Daniel C. Chambers, Jignesh K. Patel, Goran Dellgren, Miranda So, Geert M. Verleden, Emily A. Blumberg, Robin Vos, Michael Perch, Are M. Holm, Nicholas J. Mueller, Cecilia Chaparro, and Shahid Husain. Transplant Infectious Disease, February, e14251.
Optimizing Beneficence and Justice in Heart Transplant Allocation. Kittleson, Michelle M. JAMA 331 (6): 480–81.
Single Nucleotide Polymorphisms in Coronary Microvascular Dysfunction. Stein, Andrew P., Jonathan Harder, Henry R. Holmes, C. Noel Bairey Merz, Carl J. Pepine, and Ellen C. Keeley. Journal of the American Heart Association, February, e032137.
Computational Biomedicine
Large-Scale Integrative Analysis of Juvenile Idiopathic Arthritis for New Insight Into its Pathogenesis. Kim, Daeun, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung, and Wonhee Jang. Arthritis Research & Therapy 26 (1): 47.
Imaging
Coronary Artery Calcium for Stroke Mortality Prediction. Erhabor, John, Ellen Boakye, Zeina Dardari, Omar Dzaye, Garshasb Soroosh, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, John A. Rumberger, Leslee J. Shaw, Michelle C. Johansen, and Michael J. Blaha. Vascular Medicine (London, England), February, 1358863X231226217.
Medicine
Sunitinib in Patients With Breast Cancer With FGFR1 or FGFR2 Amplifications or Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study. Calfa, Carmen J., Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Eugene R. Ahn, Monika L. Burness, Keerthi Gogineni, Nitin Rohatgi, Tareq Al Baghdadi, Alison Conlin, Anu Gaba, Omid Hamid, Jairam Krishnamurthy, Naga Jyothi Gavini, Philip J. Gold, Jordi Rodon, Jens Rueter, Ramya Thota, Gina N. Grantham, Dominique C. Hinshaw, Abigail Gregory, Susan Halabi, and Richard L. Schilsky. JCO Precision Oncology 8 (February): e2300513.
From Nonalcoholic Fatty Liver Disease to Metabolic Dysfunction-Associated Steatotic Liver Disease: Out With the Old, in With the New. Alabdul Razzak, Iyiad, Mazen Noureddin, and Hirsh D. Trivedi. Journal of Clinical Medicine 13 (3): 880.
Serial Placental Growth Factor-Based Testing in Pre-Eclampsia. Cerdeira, Ana Sofia, and S. Ananth Karumanchi. Lancet (London, England), February, S0140-6736(23)02578-3.
Transcription Factor EB Modulates the Homeostasis of Reactive Oxygen Species in Intestinal Epithelial Cells to Alleviate Inflammatory Bowel Disease. Zhang, Tianci, Roufei Zhang, Wei Liu, Yucheng Qi, Hongyi Wang, Hu Zhang, Zhixiong Xiao, Stephen J. Pandol, Yuan-Ping Han, and Xiaofeng Zheng. Biochimica Et Biophysica Acta. Molecular Basis of Disease, February, 167065.
5-Hydroxymethylcytosine (5-hmC) Loss Is a Marker of Malignancy in Biliary Neoplasms. Gonzalez-Mancera, Miguel S., Andrew Siref, Kambiz Kosari, Nicholas Nissen, Srinivas Gaddam, Andrew Hendifar, Arsen Osipov, Kevin Waters, Danielle Hutchings, Maha Guindi, and Brent K. Larson. American Journal of Clinical Pathology, February, aqae001.
Differential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics. Lv, Yingqi, Xuejia Lu, Gaifang Liu, Liang Qi, Zihang Zhong, Xiaoyuan Wang, Weizhen Zhang, Ruihua Shi, Mark O. Goodarzi, Stephen J. Pandol, and Ling Li. The Journal of Clinical Endocrinology and Metabolism, February, dgae080.
Reply. Shah, Shreya A., Linus Amarikwa, Connie M. Sears, Kevin D. Clauss, Raneem D. Rajjoub, Julia Y. Kang, Madhura A. Tamhankar, César A. Briceño, Andrew R. Harrison, Kimberly P. Cockerham, Sara T. Wester, Raymond S. Douglas, Chrysoula Dosiou, and Andrea L. Kossler. Ophthalmology, February, S0161-6420(24)00003-4.
A Randomized, Double-Blind, Single-Dose, Phase 1 Study Comparing the Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Denosumab Biosimilar CT?P41 and Reference Denosumab in Healthy Males. Kim, Anhye, Jang Hee Hong, Wonsuk Shin, Hyounggyoon Yoo, Jin-Gyu Jung, Jean-Yves Reginster, SungHyun Kim, YunJu Bae, JeeHye Suh, Sera Kim, EunKyung Lee, and Stuart Silverman. Expert Opinion on Biological Therapy, February.
ABCD of IA: A Multi-Scale Agent-Based Model of T Cell Activation in Inflammatory Arthritis. McBride, David A., James S. Wang, Wade T. Johnson, Nunzio Bottini, and Nisarg J. Shah. Biomaterials Science, February.
Entinostat, Nivolumab and Ipilimumab for Women With Advanced HER2-Negative Breast Cancer: A Phase Ib Trial. Roussos Torres, Evanthia T., Won J. Ho, Ludmila Danilova, Joseph A. Tandurella, James Leatherman, Christine Rafie, Chenguang Wang, Adam Brufsky, Patricia LoRusso, Vincent Chung, Yuan Yuan, Melinda Downs, Ashley O’Connor, Sarah M. Shin, Alexei Hernandez, Elizabeth L. Engle, Richard Piekarz, Howard Streicher, Zahra Talebi, Michelle A. Rudek, Qingfeng Zhu, Robert A. Anders, Ashley Cimino-Mathews, Elana J. Fertig, Elizabeth M. Jaffee, Vered Stearns, and Roisin M. Connolly. Nature Cancer, February.
Innate and Adaptive Immune Cell Interaction Drives Inflammasome Activation and Hepatocyte Apoptosis in Murine Liver Injury From Immune Checkpoint Inhibitors. Shojaie, Layla, Jacob M. Bogdanov, Helia Alavifard, Mahmoud G. Mohamed, Aria Baktash, Myra Ali, Simeon Mahov, Sue Murray, Gary C. Kanel, Zhang-Xu Liu, Fumito Ito, Gino K. In, Akil Merchant, William Stohl, and Lily Dara. Cell Death & Disease 15 (2): 140.
Managing Risks With Newer Oral Small Molecules in Patients With Inflammatory Bowel Diseases. Ayoub, Malek, Shivani Mattay, Andres J. Yarur, and Parakkal Deepak. Current Gastroenterology Reports, February.
Neurology
Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study. Yaghi, Shadi, Liqi Shu, Daniel M. Mandel, Christopher R. Leon Guerrero, Nils Henninger, Jayachandra Muppa, Muhammad Affan, Omair Ul Haq Lodhi, Mirjam R. Heldner, Kateryna Antonenko, David J. Seiffge, Marcel Arnold, Karen L. Furie, et al. Stroke, February.
Neurosurgery
Spontaneous Sphenoid Sinus Meningocele With Associated Amenorrhea and Headache: Illustrative Case. Franklin, Deveney, Ali S. Yamani, Andre E. Boyke, Simon A. Menaker, Dennis Tang, and Adam N. Mamelak. Journal of Neurosurgery. Case Lessons 7 (7): CASE23700.
OBGYN
Associations Between Race and Ethnicity and Perioperative Outcomes Among Women Undergoing Hysterectomy for Adenomyosis. Meyer, Raanan, Christina Maxey, Kacey Hamilton, Yosef Nasseri, Moshe Barnajian, Gabriel Levin, Mireille D. Truong, Kelly N. Wright, and Matthew T. Siedhoff. Fertility and Sterility, February, S0015-0282(24)00084-0.
Author’s Reply. Caskey, Rachel, Clarissa Niino, Raanan Meyer, Rebecca Schneyer, Kacey Hamilton, Mireille Truong, Kelly Wright, and Matthew Siedhoff. Journal of Minimally Invasive Gynecology, February, S1553-4650(24)00072-4.
Orthopaedics
Arthroscopic Coracoid Transfer in the Lateral Decubitus Position Is Safe and Effective at Short-Term Follow-Up. Singla, Varun, and Michael B. Banffy. Arthroscopy, Sports Medicine, and Rehabilitation 6 (2): 100884.
Pathology and Laboratory Medicine
Characterization of T-/Natural Killer Cell Lymphoproliferative Neoplasms Associated With Systemic, Chronic, Active Epstein-Barr Virus in Adults: A Report of 5 Cases in a Western Population. Murga-Zamalloa, Carlos, Michael Brandon Stone, Marc G. Gutierrez, Neha Rajendra Hippalgaonkar, Hamza Tariq, Morteza Sadeh, Ankit Mehta, Irum Khan, Serhan Alkan, Kedar V. Inamdar, Ryan Wilcox, and Amir Behdad. American Journal of Clinical Pathology, February, aqad184.
Pediatrics
Personal Journeys to and in Human Genetics and Dysmorphology. Schwartz, Charles E., Arthur S. Aylsworth, Judith Allanson, Agatino Battaglia, John C. Carey, Cynthia J. Curry, Kay E. Davies, Evan E. Eichler, John M. Graham, Bryan Hall, Judith G. Hall, Lewis B. Holmes, H. Eugene Hoyme, Alasdair Hunter, Jeffrey Innis, John Johnson, Kim M. Keppler-Noreuil, Jules G. Leroy, Cynthia Moore, David L. Nelson, Giovanni Neri, John M. Opitz, David Picketts, F. Lucy Raymond, Stavit Allon Shalev, Roger E. Stevenson, Connie T. R. M. Stumpel, Grant Sutherland, David H. Viskochil, David D. Weaver, and Elaine H. Zackai. American Journal of Medical Genetics. Part A, February, e63514.
Radiation Oncology
Quality of Radiotherapy Workforce Training Within the USA. Mulherkar, R., D. C. Ling, R. Tendulkar, M. R. Kamrava, and S. Beriwal. Clinical Oncology (Royal College of Radiologists (Great Britain)), February, S0936-6555(24)00048-7.
Surgery
Community of Trauma Care Partnering With Stakeholders to Improve Injury Outcomes: Focus Group Analysis. Appelbaum, Rachel D., Anna Newcomb, Katherine Joseph, Morgan Hennessy, Princess Fortin, Pam J. Bixby, Sue Prentiss, Alexandra McConnell-Hill, Rochelle Flayter, Michelle A. Price, Rochelle Dicker, Rosemary Kozar, Elliott R. Haut, and Deborah M. Stein. Trauma Surgery & Acute Care Open 9 (1): e001274.
Current Recommendations for Procedure Selection in Class I and II Obesity Developed by an Expert Modified Delphi Consensus. Kermansaravi, Mohammad, Sonja Chiappetta, Chetan Parmar, Scott A. Shikora, Gerhard Prager, Teresa LaMasters, Jaime Ponce, Lilian Kow, Abdelrahman Nimeri, Shanu N. Kothari, Edo Aarts, Syed Imran Abbas, Maurizio De Luca, et al. Scientific Reports 14 (1): 3445.
A Prospective Study of Sentinel Node Biopsy Omission in Women Age???65 Years With ER+ Breast Cancer. Chung, Alice P., Catherine M. Dang, Scott R. Karlan, Farin F. Amersi, Edward M. Phillips, Marissa K. Boyle, Yujie Cui, and Armando E. Giuliano. Annals of Surgical Oncology, February.
Sinonasal Symptom Correlation With the Postoperative Polyp Scale (POPS). Wu, Arthur W., Erika A. Garcia Ruiz, Thomas S. Higgins, Dennis M. Tang, Elisa A. Illing, Taylor R. Carle, Missael Vasquez, Jonathan Y. Ting, Satyan B. Sreenath, Akaber Halawi, and Philip G. Chen. The Annals of Otology, Rhinology, and Laryngology, February, 34894241232475.
Interplay Between B7–H3 and HLA Class I in the Clinical Course of Pancreatic Ductal Adenocarcinoma. Cattaneo, Giulia, Marco Ventin, Shahrzad Arya, Filippos Kontos, Theodoros Michelakos, Yurie Sekigami, Lei Cai, Vincenzo Villani, Francesco Sabbatino, Francine Chen, Ananthan Sadagopan, Vikram Deshpande, Paul A. Moore, David T. Ting, Nabeel Bardeesy, Xinhui Wang, Soldano Ferrone, and Cristina R. Ferrone. Cancer Letters, February, 216713.
Urology
Use of Persuasive Language in Communication of Risk During Prostate Cancer Treatment Consultations. Naser-Tavakolian, Aurash, Rebecca Gale, Michael Luu, John M. Masterson, Abhishek Venkataramana, Dmitry Khodyakov, Jennifer T. Anger, Edwin Posadas, Howard Sandler, Stephen J. Freedland, Brennan Spiegel, and Timothy J. Daskivich. Medical Decision Making: An International Journal of the Society for Medical Decision Making, February, 272989X241228612.
