A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators
This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 27-Aug. 3.
Anesthesiology
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain. Jones, Jim, Darin J. Correll, Sandra M. Lechner, Ina Jazic, Xiaopeng Miao, David Shaw, Christopher Simard, Jeremiah D. Osteen, Brian Hare, Alina Beaton, Todd Bertoch, Asokumar Buvanendran, Ashraf S. Habib, Lois J. Pizzi, Richard A. Pollak, Scott G. Weiner, Carmen Bozic, Paul Negulescu, Paul F. White, and VX21-548-101 and VX21-548-102 Trial Groups. The New England Journal of Medicine 389 (5): 393–405.
Biomedical Sciences
A Nanotherapeutic Approach to Selectively Eliminate Metastatic Breast Cancer Cells by Targeting Cell Surface GRP78. Shin, Jaeho, Baksun Kim, Tyson W. Lager, Franklin Mejia, Ian Guldner, Clay Conner, Siyuan Zhang, Athanasia D. Panopoulos, and Basar Bilgicer. Nanoscale, August.
Loss of ANCO1 Expression Regulates Chromatin Accessibility and Drives Progression of Early-Stage Triple-Negative Breast Cancer. Yuan, Meng, Megan E. Barefoot, Kendell Peterson, Moray J. Campbell, Jan K. Blancato, Manjing Chen, Marcel O. Schmidt, Amber J. Kiliti, Hong-Bin Fang, Anton Wellstein, Anna T. Riegel, and Ghada M. Sharif. International Journal of Molecular Sciences 24 (14): 11505.
Cancer
Demographic Factors Predict Risk of Lymph Node Involvement in Patients With Endometrial Adenocarcinoma. Anderson, Eric M., Michael Luu, and Mitchell Kamrava. Biology 12 (7): 982.
Cardiology
Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry. Jordan, Elizabeth, Daniel D. Kinnamon, Garrie J. Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A. Ewald, Alanna A. Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W. H. Wilson Tang, Sonia Garg, Barry H. Trachtenberg, Palak Shah, Salpy V. Pamboukian, Nancy K. Sweitzer, Matthew T. Wheeler, Jane E. Wilcox, Stuart Katz, Stephen Pan, Javier Jimenez, Daniel P. Fishbein, Frank Smart, Jessica Wang, Stephen S. Gottlieb, Daniel P. Judge, Charles K. Moore, Jonathan O. Mead, Natalie Hurst, Jinwen Cao, Gordon S. Huggins, Jason Cowan, Hanyu Ni, Heidi L. Rehm, Gail P. Jarvik, Matteo Vatta, Wylie Burke, Ray E. Hershberger, and DCM Precision Medicine Study of the DCM Consortium. JAMA 330 (5): 432–41.
A Genome-Wide Association Study Identifies 41 Loci Associated With Eicosanoid Levels. Rhee, Eugene P., Aditya L. Surapaneni, Pascal Schlosser, Mona Alotaibi, Yueh-Ning Yang, Josef Coresh, Mohit Jain, Susan Cheng, Bing Yu, and Morgan E. Grams. Communications Biology 6 (1): 792.
Dynamic Cerebral Autoregulation in Postpartum Individuals With and Without Preeclampsia. Miller, Eliza C., Maria I. Katsidoniotaki, Noora Haghighi, Ketson R. M. Dos Santos, Whitney A. Booker, Nils Petersen, Ronald Wapner, Natalie A. Bello, Ioannis A. Kougioumtzoglou, and Randolph S. Marshall. Pregnancy Hypertension 33 (July): 39–45.
Rejuvenating Effects of Young Extracellular Vesicles in Aged Rats and in Cellular Models of Human Senescence. Grigorian Shamagian, Lilian, Russell G. Rogers, Kristin Luther, David Angert, Antonio Echavez, Weixin Liu, Ryan Middleton, Travis Antes, Jackelyn Valle, Mario Fourier, Liz Sanchez, Eva Jaghatspanyan, Javier Mariscal, Rui Zhang, and Eduardo Marbán. Scientific Reports 13 (1): 12240.
Outcomes of Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation According to Cardiac Resynchronization Therapy Status. Natanzon, Sharon Shalom, Alon Shechter, Robert J. Siegel, Danon Kaewkes, Keita Koseki, Aum Solanki, Ofir Koren, Brandon Schwartz, Vivek Patel, Tarun Chakravarty, Sabah Skaf, Moody Makar, Jasminka Stegic, and Raj R. Makkar. The American Journal of Cardiology 203 (July): 265–73.
Greengenes2 Unifies Microbial Data in a Single Reference Tree. McDonald, Daniel, Yueyu Jiang, Metin Balaban, Kalen Cantrell, Qiyun Zhu, Antonio Gonzalez, James T. Morton, Giorgia Nicolaou, Donovan H. Parks, Søren M. Karst, Mads Albertsen, Philip Hugenholtz, Todd DeSantis, Se Jin Song, Andrew Bartko, Aki S. Havulinna, Pekka Jousilahti, Susan Cheng, Michael Inouye, Teemu Niiranen, Mohit Jain, Veikko Salomaa, Leo Lahti, Siavash Mirarab, and Rob Knight. Nature Biotechnology, July.
Technical Recommendations for Computed Tomography Guidance of Intervention in the Right Ventricular Outflow Tract: Native RVOT Conduits and Bioprosthetic Valves: A White Paper of the Society of Cardiovascular Computed Tomography (SCCT), Congenital Heart Surgeons’ Society (CHSS), and Society for Cardiovascular Angiography & Interventions (SCAI). Han, B. Kelly, Santiago Garcia, Jamil Aboulhosn, Phillip Blanke, Mary Hunt Martin, Evan Zahn, Andrew Crean, David Overman, C. Hamilton Craig, Kate Hanneman, Thomas Semple, and Aimee Armstrong. Journal of Cardiovascular Computed Tomography, July, S1934-5925(23)00392-1.
Targeting Endothelial HIF2?/ARNT Expression for Ischemic Heart Disease Therapy. Ullah, Karim, Lizhuo Ai, Zainab Humayun, and Rongxue Wu. Biology 12 (7): 995.
Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Iskander, Mina, Yasser Jamil, John K. Forrest, Mahesh V. Madhavan, Raj Makkar, Martin B. Leon, Alexandra Lansky, and Yousif Ahmad. Structural Heart: The Journal of the Heart Team 7 (4): 100169.
Deriving Convergent and Divergent Metabolomic Correlates of Pulmonary Arterial Hypertension. Alotaibi, Mona, Yunxian Liu, Gino A. Magalang, Alan C. Kwan, Joseph E. Ebinger, William C. Nichols, Michael W. Pauciulo, Mohit Jain, and Susan Cheng. Metabolites 13 (7): 802.
Computational Biomedicine
The Role of Social Media for Identifying Adverse Drug Events Data in Pharmacovigilance: Protocol for a Scoping Review. Golder, Su, Karen O’Connor, Yunwen Wang, and Graciela Gonzalez Hernandez. JMIR Research Protocols 12 (August): e47068.
Preference Matrix Guided Sparse Canonical Correlation Analysis for Mining Brain Imaging Genetic Associations in Alzheimer’s Disease. Sha, Jiahang, Jingxuan Bao, Kefei Liu, Shu Yang, Zixuan Wen, Junhao Wen, Yuhan Cui, Boning Tong, Jason H. Moore, Andrew J. Saykin, Christos Davatzikos, Qi Long, Li Shen, and Alzheimer’s Disease Neuroimaging Initiative. Methods (San Diego, Calif.), July, S1046-2023(23)00118-4.
Discovering Venom-Derived Drug Candidates Using Differential Gene Expression. Romano, Joseph D., Hai Li, Tanya Napolitano, Ronald Realubit, Charles Karan, Mandë Holford, and Nicholas P. Tatonetti. Toxins 15 (7): 451.
Emergency Medicine
The Impact of Baseline Cervical Malalignment on the Development of Proximal Junctional Kyphosis Following Surgical Correction of Thoracolumbar Adult Spinal Deformity. Passfall, Lara, Bailey Imbo, Virginie Lafage, Renaud Lafage, Justin S. Smith, Breton Line, Andrew J. Schoenfeld, Themistocles Protopsaltis, Alan H. Daniels, Khaled M. Kebaish, Jeffrey L. Gum, Heiko Koller, D. Kojo Hamilton, Richard Hostin, Munish Gupta, Neel Anand, Christopher P. Ames, Robert Hart, Douglas Burton, Frank J. Schwab, Christopher I. Shaffrey, Eric O. Klineberg, Han Jo Kim, Shay Bess, and Peter G. Passias. Journal of Neurosurgery. Spine, July, 1–9.
Imaging
Cardiovascular Risk Stratification among Individuals With Obesity: The Coronary Artery Calcium Consortium. Boakye, Ellen, Gowtham R. Grandhi, Zeina Dardari, Rishav Adhikari, Garshasb Soroosh, Kunal Jha, Omar Dzaye, Erfan Tasdighi, John Erhabor, Sant J. Kumar, Seamus Whelton, Roger S. Blumenthal, Michael Albert, Alan Rozanski, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, John A. Rumberger, Leslee J. Shaw, and Michael Blaha. Obesity (Silver Spring, Md.), August.
Imaging Diagnosis and Management of Carpal Trauma and Instability-An Illustrated Guide. Okoro, Chukwuemeka K., Matthew R. Skalski, Dakshesh B. Patel, Eric A. White, and George R. Matcuk. Life (Basel, Switzerland) 13 (7): 1426.
The Effect of Non-Optimal Lipids on the Progression of Coronary Artery Calcification in Statin-Naïve Young Adults: Results From KOICA Registry. Lee, Heesun, Hyo-Jeong Ahn, Hyo Eun Park, Donghee Han, Hyuk-Jae Chang, Eun Ju Chun, Hae-Won Han, Jidong Sung, Hae Ok Jung, and Su-Yeon Choi. Frontiers in Cardiovascular Medicine 10: 1173289.
Medicine
Efforts to Grow Genomic Research in Ancestrally Diverse and Admixed Populations. Schmit, Stephanie L., Kristen Purrington, and Jane C. Figueiredo. Cancer Research 83 (15): 2443–44.
Endoscopic Ultrasound-Guided Coil Injection Therapy in the Management of Gastric Varices: The First U.S. Multicenter Experience. Bazarbashi, Ahmad Najdat, Elizabeth S. Aby, J. Shawn Mallery, Abdul Hamid El Chafic, Thomas J. Wang, Abdul Kouanda, Mustafa Arain, Daniel Lew, Srinivas Gaddam, Ramzi Mulki, Kondal Kyanam Kabir Baig, Sagarika Satyvada, Amitabh Chak, Ashley Faulx, Brooke Glessing, Gretchen Evans, Allison Schulman, James Haddad, Tom Tielleman, Thomas Hollander, Vladimir Kushnir, Janak Shah, and Marvin Ryou. Gastrointestinal Endoscopy, July, S0016-5107(23)02796-7.
Guided Construction of Single Cell Reference for Human and Mouse Lung. Guo, Minzhe, Michael P. Morley, Cheng Jiang, Yixin Wu, Guangyuan Li, Yina Du, Shuyang Zhao, Andrew Wagner, Adnan Cihan Cakar, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Geremy Clair, Joshua N. Adkins, Gloria S. Pryhuber, Ravi S. Misra, Bruce J. Aronow, Timothy L. Tickle, Nathan Salomonis, Xin Sun, Edward E. Morrisey, Jeffrey A. Whitsett, NHLBI LungMAP Consortium, and Yan Xu. Nature Communications 14 (1): 4566.
Corrigendum to Twenty-Year Analysis of Clinic Studies of Photobiomodulation for Oral Mucositis: A Scoping Review, Oral Surg Oral Med Oral Pathol Oral Radiol. 135 (2023) 626-641. Kauark-Fontes, Elisa, Cesar Augusto Migliorati, Joel B. Epstein, Rene-Jean Bensadoun, Luiz Alcino Monteiro Gueiros, James Carroll, Luciana Maria Pedreira Ramalho, and Alan Roger Santos-Silva. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, July, S2212-4403(23)00514-X.
Prophylactic Stenting to Decrease Incidence of Strictures After Extensive ESD in the Esophagus. The First American Experience. Ladd, Antonio Mendoza, Kenneth Park, Mohammad Bilal, Alexander Schlachterman, Sunil Amin, George Obeng, Adnan Khan, and Shyam Thakkar. Gastrointestinal Endoscopy, July, S0016-5107(23)02785-2.
Serum Identification of At-Risk MASH: The Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). Noureddin, Mazen, Emily Truong, Rebeca Mayo, Ibon Martínez-Arranz, Itziar Mincholé, Jesus M. Banales, Marco Arrese, Kenneth Cusi, María Teresa Arias-Loste, Radan Bruha, Manuel Romero-Gómez, Paula Iruzubieta, Rocio Aller, Javier Ampuero, José Luis Calleja, Luis Ibañez-Samaniego, Patricia Aspichueta, Antonio Marín-Duce, Tatyana Kushner, Pablo Ortiz, Stephen A. Harrison, Quentin M. Anstee, Javier Crespo, José M. Mato, and Arun J. Sanyal. Hepatology (Baltimore, Md.), July.
CDK4/6 Inhibitor Resistance in Hormone Receptor-Positive Metastatic Breast Cancer: Translational Research, Clinical Trials, and Future Directions. Lee, Jin Sun, Hannah Hackbart, Xiaojiang Cui, and Yuan Yuan. International Journal of Molecular Sciences 24 (14): 11791.
Higher Intra-Abdominal Visceral Adipose Tissue Mass Is Associated With Lower Rates of Clinical and Endoscopic Remission In Patients With Inflammatory Bowel Diseases Initiating Biologic Therapy: Results of the Constellation Study. Yarur, Andres J., Alexandra Bruss, Andrea Moosreiner, Poonam Beniwal-Patel, Lizbeth Nunez, Brandon Berens, Jean F. Colombel, Stephan R. Targan, Caroline Fox, Gil Y. Melmed, Maria T. Abreu, and Parakkal Deepak. Gastroenterology, July, S0016-5085(23)04774-1.
Potential Therapeutic Functions of PU-91 and Quercetin in Personalized Cybrids Derived From Patients with Age-Related Macular Degeneration, Keratoconus, and Glaucoma. Salimiaghdam, Nasim, Lata Singh, Mithalesh Kumar Singh, Marilyn Chwa, Shari Atilano, Zahra Mohtashami, Anthony Nesburn, Baruch D. Kuppermann, and M. Cristina Kenney. Antioxidants (Basel, Switzerland) 12 (7): 1326.
Endoscopic Ultrasound Guided Shear Wave Elastography Is Safe With High Feasibility and Reproducibility When Used in the Pancreas: Findings From a Prospective Cohort. Abboud, Yazan, Katherine Kim, Jamil S. Samaan, Clara Chen, Daniel Lew, Jenan Ghaith, Wendy Caldera, Mohamad Othman El Helou, Kenneth H. Park, Quin Liu, Kapil Gupta, Rabindra Watson, Simon K. Lo, Stephen J. Pandol, and Srinivas Gaddam. Pancreas 52 (2): e115–20.
Endogenous Erythropoietin Has Immunoregulatory Functions That Limit the Expression of Autoimmune Kidney Disease in Mice. Bin, Sofia, Chiara Cantarelli, Julian K. Horwitz, Micaela Gentile, Manuel Alfredo Podestà, Gaetano La Manna, Peter S. Heeger, and Paolo Cravedi. Frontiers in Immunology 14: 1195662.
OBGYN
Maternal Perceived Stress and Infant Behavior During the COVID-19 Pandemic. Bradley, Holly, Dana Fine, Yasmin Minai, Laurel Gilabert, Kimberly Gregory, Lynne Smith, Wei Gao, Gina Giase, Sheila Krogh-Jespersen, Yudong Zhang, Lauren Wakschlag, Natalie H. Brito, Integra Feliciano, Moriah Thomason, Laura Cabral, Ashok Panigrahy, Alexandra Potter, Leigh-Anne Cioffredi, and Beth A. Smith. Pediatric Research, July.
Pathology
Foxm1 Haploinsufficiency Drives Clonal Hematopoiesis and Promotes a Stress-Related Transition to Hematologic Malignancy in Mice. Yu, Chunjie, Yue Sheng, Fang Yu, Hongyu Ni, Alan Qiu, Yong Huang, and Zhijian Qian. The Journal of Clinical Investigation 133 (15): e163911.
Primary Cutaneous Epithelioid Mesenchymal Tumor With a Novel ATP2B4::GLI1 Gene Fusion. Rezaee, Neda, Brandon Cohen, Celeste Eno, and Wonwoo Shon. The American Journal of Dermatopathology, July.
PACAP and VIP Neuropeptides’ and Receptors’ Effects on Appetite, Satiety and Metabolism. Vu, John P., Leon Luong, Daniel Sanford, Suwan Oh, Alma Kuc, Rita Pisegna, Michael Lewis, Joseph R. Pisegna, and Patrizia M. Germano. Biology 12 (7): 1013.
Implications of Incomplete Immunostaining in Membranous Lupus Nephritis. Miyata, Kana N., and Cynthia C. Nast. Kidney360 4 (7): 868–69.
Clinical and Genomic Characterization of Carbapenem-Resistant Klebsiella Pneumoniae With Concurrent Production of NDM and OXA-48-like Carbapenemases in Southern California, 2016-2022. Cerón, Stacey, Zackary Salem-Bango, Deisy A. Contreras, Elizabeth L. Ranson, and Shangxin Yang. Microorganisms 11 (7): 1717.
Pediatrics
Addressing Implicit Bias and Health Disparities in a Level IV NICU. Brown-Madan, Yolanda, Amanda Williams, and Seth Langston. Journal of Perinatology, July.
Surgery
A Case of Left Carotid Artery Injury. Parvizi, David, Masa Petrovic, Jordan Kai Simmons, Amanda Bastien, and Dennis M. Tang. Ear, Nose, & Throat Journal, July, 1455613231189225.
Urology
Healthcare Costs in Men With Metastatic Castration-Resistant Prostate Cancer: An Analysis of US Medicare Fee-For-Service Claims. Freedland, Stephen J., Matthew R. Davis, Andrew J. Epstein, Bhakti Arondekar, and Jasmina I. Ivanova. Advances in Therapy, August.
A Novel Mesenchymal Stem Cell-Based Regimen for Acute Myeloid Leukemia Differentiation Therapy. Sun, Luchen, Nanfei Yang, Bing Chen, Yuncheng Bei, Zisheng Kang, Can Zhang, Nan Zhang, Peipei Xu, Wei Yang, Jia Wei, Jiangqiong Ke, Weijian Sun, Xiaokun Li, and Pingping Shen. Acta Pharmaceutica Sinica. B 13 (7): 3027–42.
