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SPEAKER 1: So the type of viral vectors that you use contains a complementary DNA. Is DNA going to get integrated into the host DNA? Or is DNA going to be transcripted and translated without any integration with the DNA of the host?
SPEAKER 2: Great question. And this really brings up the issue of type of the viruses that we use for the gene therapy strategy. I didn't associate the viral vectors which are being widely used right now in the CNS disorders. Actually, our DNA do not integrate. They remain episomal. So likelihood of having any issues as it relates to insertion and mutagenesis is very, very low.
Other type of vectors based on antiviruses or retroviruses can actually integrate as RNA viruses. And they can undergo a random insertion. So increases the chances for any potential issues as it relates to any mutagenesis.
