New Frontiers for Depression: Deep Brain Stimulation, Esketamine, and the Immune System

Drs. Mayberg, Murrough, and Nestler discuss their current research in developing personalized treatments for depression. Dr. Mayberg is a neurologist renowned for her study of brain circuits in depression and for her pioneering deep brain stimulation research, known as one of the first hypothesis-driven treatment strategies for a major mental illness. Dr. Murrough focuses on research into the variable disease pathways of depression, with the goal of differentiating subtypes of depressed patients and inventing new drugs that target these mechanisms. Dr. Nestler’s research uses animal models to delve into molecular mechanisms of depression, examining changes in gene expression and chromatin structure within the brain’s reward circuitry.

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Helen Mayberg, MD.

Helen Mayberg, MD

Helen S. Mayberg, MD, is a neurologist renowned for her study of brain circuits in depression and for her pioneering deep brain stimulation research, which has been heralded as one of the first hypothesis-driven treatment strategies for ...

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James Murrough, MD.

James Murrough, MD

Dr. James Murrough is Associate Professor of Psychiatry and Neuroscience and Director of the Depression and Anxiety Center for Discovery and Treatment at the Icahn School of Medicine at Mount Sinai. He is a Faculty member of the Friedman ...

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Eric Nestler, MD, PhD.

Eric Nestler, MD, PhD

Dr. Nestler is the Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models. Visit Eric Nestler's Laboratory ...

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