Robert Huebert, M.D., a transplant hepatologist and physician scientist in liver regenerative medicine at Mayo Clinic in Rochester, Minnesota, and Jorge Rakela, M.D., a hepatologist from Mayo Clinic in Phoenix, Arizona, discuss their article appearing in the March 2014 issue of Mayo Clinic Proceedings. They share the amazing regenerative properties of the liver, note that the need for transplantable livers has outgrown the current supply, and give great hope for new treatments for people with chronic liver disease.